Hyaluronic Acid HA

Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs

Summary:

“This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex).”

Conclusion:

“These data provide some evidence to support use of either hyaluronan plus methylprednisolone acetate or autologous conditioned plasma alone or as an adjunct to other non-surgical or surgical treatment of elbow OA and may be particularly useful for patients which cannot tolerate other disease- modifying osteoarthritis drugs such as NSAIDs. The evidence for efficacy based upon these data are relatively weak because of the study limitations, but the lack of any complications is valuable in justifying their attempted use when other therapies have failed and in justifying further study of these products to more rigorously assess their benefits.”

Author & Journal:Franklin, Samuel et al, Canadian Veterinary Journal 2013

Hyaluronic Acid Versus Saline Intra-Articular Injections for Amelioration of Chronic Knee Osteoarthritis: A Canine Model

Summary:

“The objective of this study was to assess the safety and efficacy of intra-articular injections of hyaluronic acid (HA) versus saline for symptomatic treatment of osteoarthritis (OA).”

Conclusion:

“These data suggest that currently used HA injection protocols were safe and were superior to saline for short-term amelioration of symptoms associated with chronic OA. IAHA injections resulted in clinically significant improvements with respect to pain, function, and range of motion for 4–6 months after treatment with high molecular weight HA showing the most notable and sustained beneficial effects. These findings support the safety and efficacy of IAHA as a symptomatic treatment option for patients with knee OA.”

Author & Journal:Pashuck, Troy D. et al, Journal of Orthopaedic Research, 2016

Intra-Articular Hyaluronic Acid Compared to Traditional Conservative Treatment in Dogs with Osteoarthritis Associated with Hip Dysplasia

Summary:

“The purpose of this study was to compare the efficacy of the intra-articular (IA) hyaluronic acid injection to traditional conservativetreatment (TCT) in dogs with osteoarthritis (OA) induced by hip dysplasia.”

Conclusion:

“Both treatments reduced the clinical signs associated with hip OA. However, more significant results were achieved with intra-articular hyaluronic acid injection.”

Author & Journal:Carapeba, Gabriel O. L., et al, Hindawi Evidence-Based Complementary and Alternative Medicine Journal, 2016

Mechanisms of action and potential uses of hyaluronan in dogs with osteoarthritis

Summary:

Consideration of the use of intra-articular hyaluronic acid (IAHA) for treatment of OA in dogs.

Conclusion:

“The mechanisms by which IAHA may lead to improvement in clinical signs and homeostasis in joints affected by OA may include restoration of vis- coelasticity and lubrication, antinociceptive and anti- inflammatory effects, enhancement of anabolic processes, and inhibition of catabolic processes. Because the activity of catabolic and anabolic factors in osteoarthritis is controlled by a complex network of binding proteins, cell receptors, and signaling path- ways, it is likely that these multiple effects interact with each other to result in improvement of joint health. However, in vitro findings and in vivo evidence in other species may not be directly relevant to use of this treatment in dogs. Although currently available data indicate potential benefits of using IAHA for treat- ment of OA in dogs, the authors do not recommend its clinical use until further evidence for clinical efficacy and safety in dogs with OA is provided in the literature.”

Author & Journal:Kuroki, Keiichi, et al, Journal of the American Veterinary Medical Association, 2002