Consideration of the use of intra-articular hyaluronic acid (IAHA) for treatment of OA in dogs.
“The mechanisms by which IAHA may lead to improvement in clinical signs and homeostasis in joints affected by OA may include restoration of vis- coelasticity and lubrication, antinociceptive and anti- inflammatory effects, enhancement of anabolic processes, and inhibition of catabolic processes. Because the activity of catabolic and anabolic factors in osteoarthritis is controlled by a complex network of binding proteins, cell receptors, and signaling path- ways, it is likely that these multiple effects interact with each other to result in improvement of joint health. However, in vitro findings and in vivo evidence in other species may not be directly relevant to use of this treatment in dogs. Although currently available data indicate potential benefits of using IAHA for treat- ment of OA in dogs, the authors do not recommend its clinical use until further evidence for clinical efficacy and safety in dogs with OA is provided in the literature.”