References

Long-term radiographic comparison of tibial plateau leveling osteotomy versus extracapsular stabilization for cranial cruciate ligament rupture in the dog.

Summary:

Comparison of 2 methods of surgical management of cranial cruciate ligament (CCL) injury in large-breed dogs using a radiographic osteoarthrosis (OA) scoring system.

Conclusion:

Based on logistic regression analysis, dogs with larger OA score differences were 5.78 times more likely to have had ECR than TPLO.

Author & Journal:Lazar TP, et al, Vet Surg 34:133–141, 2005

Long-term radiographic comparison of tibial plateau leveling osteotomy versus extracapsular stabilization for cranial cruciate ligament rupture in the dog.

Summary:

Comparison of 2 methods of surgical management of cranial cruciate ligament (CCL) injury in large-breed dogs using a radiographic osteoarthrosis (OA) scoring system.

Conclusion:

Based on logistic regression analysis, dogs with larger OA score differences were 5.78 times more likely to have had ECR than TPLO.

Author & Journal:Lazar TP, et al, Vet Surg. 2005 Mar-Apr;34(2):133-41

Long-term results of conservative treatment, excision arthroplasty and triple pelvic osteotomy for the treatment of hip dysplasia in the immature dog

Summary:

The efficiency of conservative treatment, excision arthroplasty of the femoral head and neck and triple pelvic osteotomy for the treatment of hip dysplasia in the immature dog were compared using locomotor, physical and radiographic examinations and owner’s evaluation.

Conclusion:

Radiographic examination demonstrated the obvious superiority of the triple pelvic osteotomy over conservative treatment for joint congruence and control of degenerative joint disease.

Author & Journal:Plante J, Dupuis, et al, Vet Comp Orthop Trauma 10: 101-110, 1997

Long-term risks and benefits of early-age gonadectomy in dogs.

Summary:

To evaluate the long-term risks and benefits of early-age gonadectomy, compared with traditional-age gonadectomy, among dogs adopted from a large animal shelter.

Conclusion:

Because early-age gonadectomy appears to offer more benefits than risks for male dogs, animal shelters can safely gonadectomize male dogs at a young age and veterinary practitioners should consider recommending routine gonadectomy for client-owned male dogs before the traditional age of 6 to 8 months. For female dogs, however, increased urinary incontinence suggests that delaying gonadectomy until at least 3 months of age may be beneficial.

Author & Journal:Spain CV, et al, JAVMA 224:380-387, 2004

Long-term risks and benefits of early-age gonadectomy in dogs.

Summary:

To evaluate the long-term risks and benefits of early-age gonadectomy, compared with traditional-age gonadectomy, among dogs adopted from a large animal shelter.

Conclusion:

Because early-age gonadectomy appears to offer more benefits than risks for male dogs, animal shelters can safely gonadectomize male dogs at a young age and veterinary practitioners should consider recommending routine gonadectomy for client-owned male dogs before the traditional age of 6 to 8 months. For female dogs, however, increased urinary incontinence suggests that delaying gonadectomy until at least 3 months of age may be beneficial.

Author & Journal:Spain CV, et al, J Am Vet Med Assoc 2004;224:380-387

Long-term treatment with carprofen of 805 dogs with osteoarthritis.

Summary:

The pain-relieving effect of carprofen and tolerance to the drug were investigated in 805 dogs that were lame as a result of osteoarthritis. The dogs were of different breeds, ages and bodyweights and of both sexes, and were selected from 51 veterinary clinics. Each dog was treated orally by its owner with 4 mg/kg carprofen for 84 consecutive days.

Conclusion:

Twenty-four dogs were removed from the study because of side effects, and 55 left the study for reasons unrelated to the treatment. The condition of the dogs and the benefit of the treatmentwere evaluated by the veterinary surgeons and the owners after 14 days, and at the end of the period of treatment, when 194 of the dogs (26.7 per cent) were no longer lame, and 357 (49.2 per cent) had improved. The period for which the dogs had been lame before entering the study significantly (P<0.01) affected the results and the rate of improvement. Too much exercise during the 84 days of treatment caused some dogs to relapse.

Author & Journal:Mansa S, et al, Vet Rec 2007;160:427-430

Low level laser therapy for tendinopathy: evidence of a dose-response pattern

Summary:

This review assessed the effects of low-level laser therapy (LLLT) on pain from tendinopathy. The authors concluded that LLLT can reduce pain in subacute and chronic tendinopathy if a valid treatment procedure and location-specific dose is used. Differences among the studies were not examined and only the short-term outcomes were assessed. The authors’ conclusions may not be reliable.

Conclusion:

Thirteen RCTs with sixteen treatment comparisons were included (n approximately 789).

Nine RCTs using optimal laser treatment dose and power density found that LLLT reduced pain in patients with sub-acute and chronic tendinopathy compared with control (WMD 32%, 95% CI: 23, 41).

Nine RCTs using optimal laser treatment dose and power density and 4 RCTs not using optimal treatment parameters found that LLLT reduced pain compared with control (WMD 22%, 95% CI: 5.9, 36.1). There was a statistically significant difference between RCTs using optimal laser treatment dose and power density and those RCTs not using optimal treatment parameters (P<0.001).

The funnel plots suggested there was potential for some publication bias.

Author & Journal:Bjordal JM, et al, Phys Therapy Rev 2001;6:91-99

Low-level laser irradiation induces in vitro proliferation of mesenchymal stem cells

Summary:

To evaluate the effect of low-level laser irradiation on the proliferation and possible nuclear morphological changes of mouse mesenchymal stem cells.

Conclusion:

Low-level laser irradiation stimulated the proliferation of mouse mesenchymal stem cells without causing nuclear alterations. The biostimulation of mesenchymal stem cells using laser therapy might be an important tool for regenerative therapy and tissue engineering.

Author & Journal:Augusto Galvão Barboza,Carlos, et al, eintstein, 2014

Low-level laser therapy induces dose-dependent reduction of TNFalpha levels in acute inflammation.

Summary:

The aim of this study was to investigate if low-level laser therapy (LLLT) can modulate acute inflammation and tumor necrosis factor (TNFalpha) levels.

Conclusion:

LLLT can reduce TNFalpha expression after acute immunocomplex lung injury in rats, but LLLT dose appears to be critical for reducing TNFalpha release.

Author & Journal:Aimbiro F, et al, Photomed Laser Surg 2006;24:33-37

Management of concurrent patellar luxation and cranial cruciate ligament rupture using modified tibial plateau levelling.

Summary:

To evaluate a novel surgery aimed at managing concurrent medial patellar luxation (MPL) and cranial cruciate ligament(CCL) ruptures in dogs weighing more than 30 kg.

Conclusion:

Thirteen surgeries were performed in 12 dogs with a mean weight of 39.8 kg. The mean postoperative tibial plateau slope was 8.1 degrees. Additional surgery was required in two cases, one due to failure of fixation and another due to screw breakage. The mean lameness score was 3.5 (out of 5) before surgery, 0.7 after 8 to 12 weeks, and 0.3 at final follow-up. Median follow-up was 1115 days (range, 270 to 2040 days). No patella luxated after surgery.

Author & Journal:Langenbach A, et al, J Small Anim Prac 2010 51:97-103