Management Archives | Page 7 of 10 | Canine Arthritis Resources and Education

Effects of treatment with polysulfated glycosaminoglycan on serum cartilage oligomeric matrix protein and C-reactive protein concentrations, serum matrix metalloproteinase-2 and -9 activities, and lameness in dogs with osteoarthritis.

Summary:

To investigate the effects of polysulfated glycosaminoglycan (PSGAG) treatment on serum cartilage oligomeric matrix protein (COMP) concentration, matrix metal-loproteinase-2 (MMP-2) and -9 (MMP-9) activities, C-reactive protein (CRP) concentration, and lameness scores in dogs with osteoarthritis.

Conclusion:

IM administration of PSGAG inhibited COMP degradation in dogs with osteoarthritis. Results indicate that decreases in serum COMP concentrations might be related to improvement in lameness after PSGAG treatment.

Author & Journal:Fujiki M, et al, Am J Vet Res 2007;68:827–833

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Comparison of lateral fabellar suture and tibial plateau leveling osteotomy techniques for treatment of dogs with cranial cruciate ligament disease.

Summary:

To compare 1-year outcomes after lateral fabellar suture stabilization (LFS) and tibial plateau leveling osteotomy (TPLO) for the treatment of dogs with cranial cruciate ligament disease.

Conclusion:

Kinematic and owner satisfaction results indicated dogs that underwent TPLO had better outcomes than those that underwent LFS.

Author & Journal:Gordon-Evans WJ, et al, J Am Vet Med Assoc 243:675-680, 2013

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Comprehensive OA Management: The CARE Quad

The phrase “multi-modal management” is not a new concept in the treatment of canine OA. In fact, it was popularized in the early 2000s when veterinarians began to recognize there are options beyond “Rest and Rimadyl.” To be clear, Rimadyl […]

Evidence-Based Medicine vs. Evidence-Guided Medicine

The practice of evidence-based medicine (EBM) can be described as the effort to make medical decisions based on the strongest scientific evidence available. Evidence can be categorized into hierarchal levels according to the quality of research and the likelihood that […]

VIDEO: Surgical Treatment for the Elbow: OC/OCD

Dr. Kirkby Shaw describes the most common surgical options for OC/OCD (a type of elbow dysplasia). Read more about OC/OCD and elbow dysplasia. USE THIS LINK to share with clients: https://youtu.be/lg_mOCGoEy4

Anti-inflammatory pain medications

A review of how anti-inflammatories work and different available classes The Arachidonic Acid Cascade Every cell in the body is surrounded by a phospholipid bilayer (cell membrane) that is made of polyunsaturated fats. Arachidonic acid (AA) is part of the […]

Pain Management: NSAIDs overview

Osteoarthritis is the most common cause of chronic pain in dogs. Pain management must be the foundation for treating OA and preserving the quality of life. The phrase “quality of life” is most often used when discussing end-of-life decision making […]

Pain Management: Adjunctive Oral Analgesics

Adjunctive Oral Analgesics: Targeting the peripheral and central nervous system While NSAIDs are currently considered the foundation of oral pain management for dogs with OA, it is important to recognize that PGE2/EP4 (the target of NSAIDs) is only one of […]

What is Adequan and how does it help OA?

Adequan is the brand name for polysulfated glycosaminoglycan (PSGAG). Adequan is approved by the FDA for the management of OA in dogs and horses and labeled as a disease-modifying osteoarthritic drug. Adequan protects cartilage and decreases inflammation by inhibiting the […]

Intra-Articular Therapies for OA

Overview of Joint Injections Osteoarthritis is currently an incurable and irreversible condition, but there are a lot of tools that can be effective at managing the progression and symptoms. Intra-articular (IA) therapy, i.e. joint injections, have traditionally been recommended if […]