Summary: The aim of this randomized, placebo‐controlled and double‐blinded trial was to compare the effect of a veterinary therapeutic diet (VTD) rich in omega‐3 fatty acids (omega‐3) from fish origin to a regular diet used as control (CTR) over a period of 13 weeks in dogs afflicted by naturally occurring osteoarthritis (OA). Thirty privately owned dogs were selected. Dogs had lameness confirmed by an orthopaedic examination, had stifle/hip OA and had locomotor disability based on the peak of the vertically oriented ground reaction force (PVF) measured using a force platform. At Baseline, all owners were asked to determine 2–5 activities of daily living that were the most impaired. Activities were scores (0–4) in accordance with severity using case‐specific outcome measures (CSOM). The PVF was also measured. Dogs (15/group) were then randomly assigned to receive either the CTR or the VTD. The CSOM was completed twice weekly. The recording of PVF was repeated at Week 7 and 13. The VTD‐fed dogs showed a significantly higher PVF at Week 7 (p < 0.001) and at Week 13 (p < 0.001) when compared to Baseline. From Baseline to Week 13, VTD‐fed dogs had a mean (± SD) change in PVF recording of 3.5 ± 6.8% of body weight (%BW) compared with 0.5 ± 6.1%BW (p = 0.211) in CTR‐fed dogs. This change in the primary outcome was consistent with an effect size of 0.5. Conversely, dogs fed the CTR did not show significant change in PVF measurements. At the end of the study, the CSOM was significantly decreased (p = 0.047) only in VTD fed dogs. In lame OA dogs, a VTD that contains high level of omega‐3 from fish origin improved the locomotor disability and the performance in activities of daily living. Such nutritional approach appears interesting for the management of OA.
Citing Literature
Conclusion: This clinical trial evaluated the functional outcomes of lame privately owned dogs afflicted by OA follow- ing 13 weeks of feeding with a VTD containing high levels of omega-3. According to the primary study outcome (PVF), OA dogs were significantly improved (p < 0.001) 7 weeks after the beginning of a dietary modulation. The improvement in the functional disability was maintained through the 13 weeks duration, achieving a mean improvement of 3.5 ± 6.8%BW when compared to initial limb support (p < 0.001). When expressed relatively to Baseline (pre-treatment) values, the improvement corresponded to 6.9 ± 12.2%. The ameliorative effect of VTD was in accordance with previous trials performed by our group (Moreau et al., 2003, 2004, 2007) and others (Budsberg et al., 1999) using NSAID and powder of elk velvet antler. Moreover, the level of improvement represented an increment of 1.4 kg applied to the afflicted and painful limb for a dog of 36.7 kg. The effect size of the VTD improvement was 0.5, which was consistent with a moderate therapeutic effect (Cohen, 1992).
Author & Journal:M. Moreau, E. Troncy, J. R. E. del Castillo, C. Bédard, D. Gauvin, B. Lussier, J Anim Physiol Anim Nutr (Berl).
