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Platelet Rich Plasma PRP

Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs

Summary:

“This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex).”

Conclusion:

“These data provide some evidence to support use of either hyaluronan plus methylprednisolone acetate or autologous conditioned plasma alone or as an adjunct to other non-surgical or surgical treatment of elbow OA and may be particularly useful for patients which cannot tolerate other disease- modifying osteoarthritis drugs such as NSAIDs. The evidence for efficacy based upon these data are relatively weak because of the study limitations, but the lack of any complications is valuable in justifying their attempted use when other therapies have failed and in justifying further study of these products to more rigorously assess their benefits.”

Author & Journal:Franklin, Samuel et al, Canadian Veterinary Journal 2013
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Partial Cranial Cruciate Ligament Tears Treated with Stem Cell and Platelet-Rich Plasma Combination Therapy in 36 Dogs: A Retrospective Study.

Summary:

To evaluate outcomes in 36 dogs with a partial cranial cruciate ligament (CCL) tear treated with autologous bone marrow aspirate concentrate (BMAC) or adipose-derived progenitor cells (ADPC) with platelet-rich plasma (PRP) combination.

Conclusion:

Stifle arthroscopy findings at 90 days posttreatment were available on 13 of the 36 dogs. In nine dogs, a fully intact CCL with marked neovascularization and a normal fiber pattern was found with all previous regions of disruption healed. One dog revealed significant improvement and received an additional injection. The remaining three dogs had a >50% CCL tear, and a TPLO was performed. Four additional dogs were known to have had a TPLO performed elsewhere. Baseline and day 90 posttreatment objective gait analyses were available on 11 of the 36 dogs. A significant difference was found between the treated limb total pressure index percent (TPI%) at day 0 and day 90 (p = 0.0124), and between the treated limb and contralateral limb TPI% at day 0 (p = 0.0003). No significant difference was found between the treated limb and contralateral limb TPI% at day 90 (p = 0.7466). Twelve questionnaires were returned, of which eight were performance/sporting dogs. Seven of the eight had returned to sport; the remaining dog had just begun a return to sport conditioning program 6 months posttreatment. All 12 respondents believed that their dog had an excellent or very good quality of life and rated their dog’s procedural outcome as excellent or good.

Author & Journal:Canapp SO, et al, Frontiers Vet Sci 2016 doi: 10.3389/fvets.2016.00112
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Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency.

Summary:

Platelet rich plasma (PRP) is used to treat many musculoskeletal disorders. We used a canine model to determine the effects of multipleintra-articular injections of leukoreduced PRP (ACP) on anterior cruciate ligament healing, meniscal healing, and progression of osteoarthritis (OA).

Conclusion:

Five intra-articular injections of leukoreduced PRP had beneficial effects for ACL healing, improved range of motion, decreased pain, and improved limb function for up to 6 months in this model.

Author & Journal:Cook JL, et al, J Orthop Res 2016; 34(4):607-615
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A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs.

Summary:

To determine efficacy of a single intra-articular injection of an autologous platelet concentrate for treatment of osteoarthritis in dogs.

Conclusion:

Results suggested that a single intra-articular injection of autologous platelets resulted in significant improvements at 12 weeks in dogs with osteoarthritis involving a single joint.

Author & Journal:Fahie MA, et al, J Am Vet Med Assoc 2013;243:1291-1297
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Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs

Summary:

This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP®; Arthrex)

Conclusion:

With respect to client-based functional assessments over time, statistically significant improvements in scores for activity, lameness, pain, and overall function categories were noted for both groups over the study period with most changes being > 10% in magnitude. The greatest improvements in client-based assessment scores for dogs receiving HA and corticosteroid were noted at 1 wk post-injection for pain and activity and at 12 wk post-injection for lameness. All improvements in client-based assessments for dogs in the group receiving ACP were greatest at 6 wk post-injection.

Author & Journal:Franklin SP, et al, Can Vet J 2013;54:881-884
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Evaluation of a Single Intra-Articular Injection of Autologous Protein Solution for Treatment of Osteoarthritis in a Canine Population.

Summary:

To evaluate the safety and efficacy of an intra-articular injection of autologous protein solution (APS) for treatment of canine osteoarthritis (OA).

Conclusion:

APS injection reduced pain and lameness scores and increased weight-bearing associated with the OA-affected joint in dogs at 12 weeks providing preliminary evidence that APS therapy may be beneficial in the treatment of OA in dogs and supporting pursuit of additional studies.

Author & Journal:Wanstrath AW, et al, Vet Surg 2016;45:764-774
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Effects of administration of adipose-derived stromal vascular fraction and platelet-rich plasma to dogs with osteoarthritis of the hip joints.

Summary:

To evaluate effects of simultaneous intra-articular and IV injection of autologous adipose-derived stromal vascular fraction (SVF) and platelet-rich plasma (PRP) to dogs with osteoarthritis of the hip joints. ANIMALS 22 client-owned dogs (12 placebo-treated [control] dogs and 10 treated dogs).

Conclusion:

For dogs with osteoarthritis of the hip joints treated with SVF and PRP, improvements in CBPI and PVF were evident at some time points, compared with results for the control group.

Author & Journal:Upchurch DA, et al, Am J Vet Res 2016;77:940-951
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