Summary: Modification of metabolic responses for cholesterol and other lipids as a result of dietary methods or drugs has been extensively studied in humans and laboratory animals, and much has been published on this topic. However, less is known about this topic in small companion animals, such as dogs and cats. One of the reasons is that compared to humans, cats and dogs are typically resistant to coronary artery disease, myocardial infarction, cerebral vascular stroke, and atherosclerosis. Thus, they are rarely studied in regard to these disorders. Nonetheless, dogs are especially useful in the evaluation of compounds that lead to important discoveries of drugs for humans. Therefore, knowledge of canine cholesterol, fatty acid, and lipoprotein metabolism must be understood for these comparative purposes.
Conclusion: Progress has been made during the past years in several areas of fatty acid metabolism and nutrition for dogs. Renal and cardiovascular diseases may be amenable to dietary management with omega-3 fatty acids. Dietary changes to cause improvements in skin and coat exist, and although related to total dietary fat content, additional benefits can be derived when these diets contain higher amounts of polyunsatu- rated fats. The addition of ALA to a diet containing LA results in further accumulation of LA in plasma, which may contribute to a sparing effect on LA. This phenomenon may indirectly promote skin and coat benefits.
Author & Journal:John E. Bauer, DVM, Ph.D., DACVN, J Am Vet Med Assoc.