Nutrition

Weight management in obese pets: the tailoring concept and how it can improve results.

Summary:

Obesity is now recognised as the most important medical disease in pets worldwide.

Conclusion:

In this opinionated review, the author will discuss findings from recent clinical research studies examining weight management in obese dogs and cats. A strategy for tailoring weight management targets will then be discussed, illustrated with case examples.

Author & Journal:German AJ, Acta Vet Scand 2016;58:57

Evaluation of the clinical effects of diet and physical rehabilitation in dogs following tibial plateau leveling osteotomy

Summary:

To assess clinical effects of an omega-3 fatty acid and protein-enriched diet, physical rehabilitation, or both in dogs following tibial plateau leveling osteotomy (TPLO) and arthroscopic surgery for cranial cruciate ligament (CCL) disease.

Conclusion:

Feeding the TF and providing physical rehabilitation during the first 6 months after TPLO were associated with improvements in some indices of clinical outcome and function in dogs. Significant interactions between time and some outcome variables were observed, indicating further research is warranted.

Author & Journal:Baltzer WI, et al, J Am Vet Med Assoc 252:686-700, 2018

Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination with Glucosamine and Chondroitin in Arthritic Dogs.

Summary:

This investigation was undertaken to evaluate the therapeutic efficacy and safety of glycosylated undenatured type II collagen (UC-II) alone or in combination with glucosamine HCl and chondroitin sulfate in arthritic dogs.

Conclusion:

None of the dogs in any groups showed any adverse effects or change in liver or kidney function markers or body weight. Data of this placebo-controlled study demonstrate that daily treatment of arthritic dogs with UC-II alone or in combination with glucosamine and chondroitin markedly alleviates arthritic-associated pain, and these supplements are well tolerated as no side effects were noted.

Author & Journal:D’Altilio M, et al, Toxicol Mech Methods. 2007;17(4):189-96.

A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog.

Summary:

Obesity is an increasingly important health problem for both man and dog. Osteoarthritis (OA) is a significant cause of pain and disability in both species. A link between obesity and OA has been established in man, though the exact mechanism of the relationship remains to be fully elucidated – current research supports both biomechanical and biochemical theories. There is good evidence (class I*) to support weight loss as an effective treatment for human knee OA. In the dog, the relationship is just beginning to be investigated.

Conclusion:

Further research could yield greater understanding of the pathophysiology of this relationship, perhaps identifying novel therapeutic targets. Confirmation and better understanding of the positive effect of treating and preventing obesity on symptoms and prevalence of OA is likely to be valuable in the campaign against canine obesity.

Author & Journal:Marshall WG, et al, Vet Comp Orthop Trauamatol 2009;22:339-345

Canine Hip Dysplasia: Reviewing the Evidence for Nonsurgical Management

Summary:

This systematic review of available evidence for nonsurgical management of hip dysplasia considered 14 articles and scored nonsurgical management including: activity restrictions, weight management, acupuncture, modulation of joint disease by polysulfated glycosaminoglycans, mesenchymal stem cell therapy, and extra corporeal shock wave therapy.

Conclusion:

“Weight management is an effective and important component of managing dogs with HD and associated osteoarthritis. Techniques that modulate the progression of joint disease may also be beneficial for treating dogs with HD. Further studies are needed to investigate other methods of managing HD such as hydrotherapy and physical rehabilitation.”

Author & Journal:Shaw, Kristin Kirkby et al, Veterinary Surgery, 2012

Success of a weight loss plan for overweight dogs: The results of an international weight loss study.

Summary:

Obesity is a global concern in dogs with an increasing prevalence, and effective weight loss solutions are required that work in different geographical regions. The main objective was to conduct an international, multi-centre, weight loss trial to determine the efficacy of a dietary weight loss intervention in obese pet dogs.

Conclusion:

This is the largest international multi-centre weight loss study conducted to date in obese dogs. Most dogs lost a clinically significant amount of weight, although there were notable differences between dogs of different sex, neuter status and in different geographical locations.

Author & Journal:Flanagan J, PLOS One 2017

Assessment of the effects of diet and physical rehabilitation on radiographic findings and markers of synovial inflammation in dogs following tibial plateau leveling osteotomy

Summary:

To determine the effects of an omega-3 fatty acid and protein-enriched diet, physical rehabilitation, or both on radiographicfindings and markers of synovial inflammation in dogs following tibial plateau leveling osteotomy and arthroscopic surgery for treatment of cranial cruciate ligament disease. DESIGN Randomized, prospective clinical trial. ANIMALS 48 dogs with unilateral cranial cruciate ligament disease.

Conclusion:

Results suggested that feeding the TF can result in lower synovial fluid PGE2 concentrations and that both the TF and rehabilitation can reduce progression of osteoarthritis in the 6 months following tibial plateau leveling osteotomy; clinical relevance of slower osteotomy healing in dogs fed the TF was unclear.

Author & Journal:Verpaalen VD, et al, J Am Vet Med Assoc 252:701-709, 2018

Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus)

Summary:

A green-lipped mussel (GLM) preparation was evaluated in a randomized, double-controlled and double-blinded clinical trial. It was hypothesized that the treatment effect would be less than that of the positive control (carprofen) but more than that of the negative control (placebo).

Conclusion:

In conclusion, our results suggest that the modern stabilized and freeze-dried GLM is more effective than the placebo in treating chronic pain due to moderate to severe OA and that it has no side-effects. For dogs that can not use NSAIDs or corticosteroids and for patients who need analgesic support over extended periods of time, oral GLM may be an acceptable alternative for treating chronic arthritis pain, although it does not alleviate pain as well as carprofen. As dogs are used as models for human OA, we hope these promising results will stimulate new human research in this area.

Author & Journal:Hielm-bjorkman A, et al, Evid Based Complement Alternat Med. 2009 Sep; 6(3): 365–373