Steroids (triamcinolone)
Steroid injections are a common treatment of arthritis in people and animals.
However, we know that repeated steroid injections can be detrimental to the cartilage, so we typically recommend reserving steroid injections as a last resort for “end-stage” disease when there is little to no cartilage remaining.
Steroids can be effective in decreasing inflammation and pain in the joint. Steroids are typically combined with HA when administered.
One study showed equivalent results of HA plus steroids vs. ACP (Arthrex brand of PRP). Improvements were seen as soon as 1 week after injection and lasted at least 12 weeks (Franklin SP 2013).
References
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Black LL, Gaynor J, Adams C, et al. Effects of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Therapeutics 2008.
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Upchurch DA, Renberg WC, Roush JK, et al. Effects of administration of adipose-derived stromal vascular fraction and platelet-rich plasma to dogs with osteoarthritis of the hip joints. Am J Vet Res 2016;77:940-951.
Kuroki K, Cook JL, Kreeger JM. Mechanisms of action and potential uses of hyaluronan in dogs with osteoarthritis. J Am Vet Med Assoc 2002;221:944-950.
Canapp SO, Cross AR, Brown MP, et al. Examination of synovial fluid and serum following intravenous injections of hyaluronan for the treatment of osteoarthritis in dogs. Vet Comp Orthop Traumatol 2005;18:19-174.
Smith GN, Mickler EA, Myers SL, Brandt KD. Effect of intraarticular hyaluronan injections on synovial fluid hyaluronan in the early stage of canine post-traumatic osteoarthritis. J Rheumatol 2001;28:1341-1346.
Pashuck TD, Kuroki K, Cook CR, et al. Hyaluronic acid versus saline intra-articular injections for amelioration of chronic knee osteoarthritis: A canine model. J Orthop Res 2016; 34:1772-1779.
Carapebe GOL, Cavaleti P, Nicacio GM, et al. Intra-articular hyaluronic acid compared to traditional conservative treatment in dogs with osteoarthritis associated with hip dysplasia. Evidence-Based Comp Alt Med 2016.
